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- DNA combing versus DNA spreading and the separation of sister chromatids. Meroni A, Wells SE, Fonseca C, Ray Chaudhuri A, Caldecott KW, Vindigni A. J Cell Biol. 2024 Apr 1;223(4):e202305082. doi: 10.1083/jcb.202305082. Epub 2024 Feb 5. PMID: 38315097
- The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress. O’Leary DR, Hansen AR, Fingerman DF, Tran T, Harris BR, Hayer KE, Fan J, Chen E, Tennakoon M, DeWeerd RA, Meroni A, Szeto JH, Weitzman MD, Shalem O, Bednarski J, Vindigni A, Zhao X, Green AM. EMBO J. 2024 Jun 17. doi: 10.1038/s44318-024-00137-x. Online ahead of print. PMID: 38886382
- A RAD18-UBC13-PALB2-RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells. Cybulla E, Wallace S, Meroni A, Jackson J, Agashe S, Tennakoon M, Limbu M, Quinet A, Lomonosova E, Noia H, Tirman S, Wood M, Lemacon D, Fuh K, Zou L, Vindigni A. Nucleic Acids Res. 2024 Jun 29:gkae563. doi: 10.1093/nar/gkae563. Online ahead of print. PMID: 38943334
- Nucleolytic processing of abasic sites underlies PARP inhibitor hypersensitivity in ALC1-deficient BRCA mutant cancer cells. Ramakrishnan N, Weaver TM, Aubuchon LN, Woldegerima A, Just T, Song K, Vindigni A, Freudenthal BD, Verma P. Nat Commun. 2024 Jul 27;15(1):6343. doi: 10.1038/s41467-024-50673-7. PMID: 39068174
- Rapid profiling of DNA replication fork dynamics using mass spectrometry-based analysis of nascent DNA. Ashour ME, Byrum AK, Meroni A, Xia J, Singh S, Galletto R, Rosenberg SM, Vindigni A, Mosammaparast N. J. Cell Biol. 2023, Apr 3;222(4):e202207121. PMID: 36795402
- RAD51 bypasses the CMG helicase to promote replication fork reversal. Liu W, Saito Y, Jackson J, Bhowmick R, Kanemaki MT, Vindigni A, Cortez D. Science. 2023 Apr 28;380(6643):382-387. doi: 10.1126/science.add7328. PMID: 37104614
- ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms. Leung W, Simoneau A, Saxena S, Jackson J, Patel PS, Limbu M, Vindigni A, Zou L. Cell Rep. 2023 Jul 25;42(7):112792. PMID: 37454295
- Leveraging replication stress response to optimize cancer therapy. Cybulla E. Vindigni A. Nat. Rev. Cancer 2023 Jan;23(1):6-24. PMID: 36323800
- GAS6/AXL inhibition enhances ovarian cancer sensitivity to chemotherapy and PARP inhibition through increased DNA damage and enhances replication stress. Mullen MM, Lomonosova E, Toboni MD, Oplt A, Cybulla E, Blachut B, Zhao P, Noia H, Wilke D, Rankin EB, Kuroki LM, Hagemann AR, Hagemann IS, McCourt CK, Thaker PH, Mutch DG, Powell MA, Mosammaparast N, Vindigni A, Fuh KC. Mol. Cancer Res 2022 Feb;20(2):265-279. PMID: 34670865
- NEDDylated-Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors. Meroni A, Grosser J, Agashe S, Ramakrishnan N, Jackson J, Verma P, Baranello L, Vindigni A. Sci. Adv. 2022 Dec 9;8(49):eabq0648. PMID: 36490343
- Profilin-1 regulates DNA replication forks in a context-dependent fashion by interacting with SNF2H and BOD1L. Zhu C, Iwase M, Li Z, Wang F, Quinet A, Vindigni A, Shao J. Nat. Comm. 2022 Nov 1;13(1):6531. PMID: 36319634
- Studying single stranded DNA gaps at replication intermediates by electron microscopy. Jackson J, Vindigni A. Methods Mol. Biol. 2022; 2444:81-103. PMID: 35290633
- A RADAR method to measure DNA topoisomerase covalent complexes. Meroni A, Vindigni A. Methods Enzymol. 2022;672:369-381. PMID: 35934484
- CARM1 regulates replication fork speed and stress response by stimulating PARP1. Genois MM, Gagné JP, Yasuhara T, Jackson J, Saxena S, Langelier MF, Ahel I, Bedford MT, Pascal JM, Vindigni A, Poirier GG, Zou L. Mol. Cell. 2021 Feb 18;81(4):784-800.e8. PMID: 33412112
- PRIMPOL ready, set, reprime! Tirman S, Cybulla E, Quinet A, Meroni A, Vindigni A. Crit. Rev. Biochem. Mol. Biol. 2021 Feb;56(1):17-30. PMID: 33179522
- To skip or not to skip: choosing repriming to tolerate DNA damage. Quinet A, Tirman S, Cybulla E, Meroni A, Vindigni A. Mol. Cell 2021 Feb 18;81(4):649-658. PMID: 33515486
- Entinostat, a selective HDAC1/2 inhibitor, potentiates the effects of olaparib in homologous recombination proficient ovarian cancer. Gupta VG, Hirst J, Petersen S, Roby KF, Kusch M, Zhou H, Clive ML, Jewell A, Pathak HB, Godwin AK, Wilson AJ, Crispens MA, Cybulla E, Vindigni A, Fuh KC, Khabele D. Gynecol. Oncol. 2021 Apr 15:S0090-8258(21)00325-5. PMID: 33867143
- Telomere erosion in human pluripotent stem cells leads to ATR-mediated mitotic catastrophe. Vessoni AT, Zhang T, Quinet A, Jeong HC, Munroe M, Wood M, Tedone E, Vindigni A, Shay JW, Greenberg RA, Batista LFZ. J. Cell. Biol. 2021 Jun 7;220(6):e202011014. PMID: 33851958
- RADX prevents genome instability by confining replication fork reversal to stalled replication forks. Krishnamoorthy A, Jackson J, Mohamed T, Adolph M, Vindigni A, Cortez D. Mol. Cell 2021 Jul 15;81(14):3007-3017.e5.PMID: 34107305
- Lamin-A/C recruits ssDNA protective proteins RPA and RAD51 to stalled replication forks to maintain fork stability. Graziano S, Coll-Bonfill N, Teodoro-Castro B, Kuppa S, Jackson J, Shashkova E, Mahajan U, Vindigni A, Antony E, Gonzalo S. J Biol Chem. 2021 Oct 11:101301. PMID: 34648766
- Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells. Tirman S, Quinet A, Wood M, Meroni A, Cybulla E, Jackson J, Pegoraro S, Simoneau A, Zou L, Vindigni A. Mol. Cell 2021 Oct 7;81(19):4026-4040.e8. PMID: 34624216
- Aberrant RNA methylation triggers recruitment of an alkylation repair complex. Tsao N, Brickner JR, Rodell R, Ganguly A, Wood M, Oyeniran C, Ahmad T, Sun H, Bacolla A, Zhang L, Lukinović V, Soll JM, Townley BA, Casanova AG, Tainer JA, He C, Vindigni A, Reynoird N, Mosammaparast N. Mol. Cell 2021 Oct 21;81(20):4228-4242.e8. PMID: 34686315