Publications

GAS6/AXL inhibition enhances ovarian cancer sensitivity to chemotherapy and PARP inhibition through increased DNA damage and enhances replication stress.
Mullen MM, Lomonosova E, Toboni MD, Oplt A, Cybulla E, Blachut B, Zhao P, Noia H, Wilke D, Rankin EB, Kuroki LM, Hagemann AR, Hagemann IS, McCourt CK, Thaker PH, Mutch DG, Powell MA, Mosammaparast N, Vindigni A, Fuh KC.
Mol. Cancer Res 2022 Feb;20(2):265-279. PMID: 34670865

Studying single stranded DNA gaps at replication intermediates by electron microscopy.
Jackson J, Vindigni A.
Methods Mol. Biol. 2022; 2444:81-103. PMID: 35290633

A RADAR method to measure DNA topoisomerase covalent complexes.
Meroni A, Vindigni A.
Methods Enzymol. 2022;672:369-381. PMID: 35934484

Temporally Distinct Post-Replicative Repair Mechanisms Fill PRIMPOL-Dependent ssDNA Gaps in Human Cells
Tirman S, Quinet A, Wood M, Meroni A, Cybulla E, Jackson J, Pegoraro S, Simoneau A, Zou L, Vindigni A
Mol Cell 2021 Oct 7;81(19):4026-4040

Aberrant RNA Methylation Triggers Recruitment of an Alkylation Repair Complex
Tsao N, Brickner JR, Rodell R, Ganguly A, Wood M, Oyeniran C, Ahmad T, Sun H, Bacolla A, Zhang L, Lukinovic V, Soll JM, Townley BA, Casanova AG, Tainer JA, He C, Vindigni A, Reynoird N, Mosammaparast N
Mol Cell 2021 Oct 21;81(20):4228-4242

Lamin A/C Recruits ssDNA Protective Proteins RPA and RAD51 to Stalled Replication Forks to Maintain Fork Stability
Graziano S, Coll-Bonfill N, Teodoro-Castro B, Kuppa S, Jackson J, Shashkova E, Mahajan U, Vindigni A, Antony E, Gonzalo S
J Biol Chem 2021 Nov;297(5):101301

RADX Prevents Genome Instability by Confining Replication Fork Reversal to Stalled Forks
Krishnamoorthy A, Jackson J, Mohamed T, Adolph M, Vindigni A, Cortez D
Mol Cell 2021 May 29; [Epub ahead of print]

Entinostat, a Selective HDAC1/2 Inhibitor, Potentiates the Effects of Olaparib in Homologous Recombination Proficient Ovarian Cancer
Gupta VG, Hirst J, Petersen S, Roby KF, Kusch M, Zhou H, Clive ML, Jewell A, Pathak HB, Godwin AK, Wilson AJ, Crispens MA, Cybulla E, Vindigni A, Fuh KC, Khabele D
Gynecol Oncol 2021 Apr 15; [Epub ahead of print]

Telomere Erosion in Human Pluripotent Stem Cells Leads to ATR-Mediated Mitotic Catastrophe
Vessoni AT, Zhang T, Quinet A, Jeong HC, Munroe M, Wood M, Tedone E, Vindigni A, Shay JW, Greenberg RA, Batista LFZ
J Cell Biol 2021 Jun 7;220(6):e202011014

To Skip or Not to Skip: Choosing Repriming to Tolerate DNA Damage
Quinet A, Tirman S, Cybulla E, Meroni A, Vindigni A
Mol Cell 2021 Feb 18;81(4):649-658

CARM1 Regulates Replication Fork Speed and Stress Response by Stimulating PARP1
Genois MM, Gagne JP, Yasuhara T, Jackson J, Saxena S, Langelier MF, Ahel I, Bedford MT, Pascal JM, Vindigni A, Poirier GG, Zou L
Mol Cell 2021 Feb 18;81(4):784-800e8

PRIMPOL Ready, Set, Reprime!
Tirman S, Cybulla E, Quinet A, Meroni A, Vindigni A
Crit Rev Biochem Mol Biol 2021 Feb;56(1):17-30