Published Work

2021

RADX Prevents Genome Instability by Confining Replication Fork Reversal to Stalled Forks
Krishnamoorthy A, Jackson J, Mohamed T, Adolph M, Vindigni A, Cortez D
Mol Cell 2021 May 29; [Epub ahead of print]

Entinostat, a Selective HDAC1/2 Inhibitor, Potentiates the Effects of Olaparib in Homologous Recombination Proficient Ovarian Cancer
Gupta VG, Hirst J, Petersen S, Roby KF, Kusch M, Zhou H, Clive ML, Jewell A, Pathak HB, Godwin AK, Wilson AJ, Crispens MA, Cybulla E, Vindigni A, Fuh KC, Khabele D
Gynecol Oncol 2021 Apr 15; [Epub ahead of print]

Telomere Erosion in Human Pluripotent Stem Cells Leads to ATR-Mediated Mitotic Catastrophe
Vessoni AT, Zhang T, Quinet A, Jeong HC, Munroe M, Wood M, Tedone E, Vindigni A, Shay JW, Greenberg RA, Batista LFZ
J Cell Biol 2021 Jun 7;220(6):e202011014

To Skip or Not to Skip: Choosing Repriming to Tolerate DNA Damage
Quinet A, Tirman S, Cybulla E, Meroni A, Vindigni A
Mol Cell 2021 Feb 18;81(4):649-658

CARM1 Regulates Replication Fork Speed and Stress Response by Stimulating PARP1
Genois MM, Gagne JP, Yasuhara T, Jackson J, Saxena S, Langelier MF, Ahel I, Bedford MT, Pascal JM, Vindigni A, Poirier GG, Zou L
Mol Cell 2021 Feb 18;81(4):784-800e8

PRIMPOL Ready, Set, Reprime!
Tirman S, Cybulla E, Quinet A, Meroni A, Vindigni A
Crit Rev Biochem Mol Biol 2021 Feb;56(1):17-30

2020

Homologous Recombination Deficiency Real-Time Clinical Assays, Ready or Not?
Fuh K, Mullen M, Blachut B, Stover E, Konstantinopoulos P, Liu J, Matulonis U, Khabele D, Mosammaparast N, Vindigni A
Gynecol Oncol 2020 Dec;159(3):877-886

TDP-43 Dysfunction Results in R-Loop Accumulation and DNA Replication Defects
Wood M, Quinet A, Lin YL, Davis AA, Pasero P, Ayala YM, Vindigni A
J Cell Sci 2020 Sep 28; [Epub ahead of print]

Homologous Recombination Deficiency Real-Time Clinical Assays, Ready or Not?
Fuh K, Mullen M, Blachut B, Stover E, Konstantinopoulos P, Liu J, Matulonis U, Khabele D, Mosammaparast N, Vindigni A
Gynecol Oncol 2020 Sep 20; [Epub ahead of print]

ISG15 Fast-Tracks DNA Replication
Meroni A, Vindigni A
J Cell Biol 2020 Aug 3;219(8)

Inhibition of the Translesion Synthesis Polymerase REV1 Exploits Replication Gaps as a Cancer Vulnerability
Nayak S, Calvo JA, Cong K, Peng M, Berthiaume E, Jackson J, Zaino AM, Vindigni A, Hadden MK, Cantor SB
Sci Adv 2020 Jun 10;6(24):eaaz7808

The Multifunctional Protein PACS-1 Is Required for HDAC2- and HDAC3-Dependent Chromatin Maturation and Genomic Stability
Mani C, Tripathi K, Luan S, Clark DW, Andrews JF, Vindigni A, Thomas G, Palle K
Oncogene 2020 Mar;39(12):2583-2596

PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells
Quinet A, Tirman S, Jackson J, Svikovic S, Lemacon D, Carvajal-Maldonado D, Gonzalez-Acosta D, Vessoni AT, Cybulla E, Wood M, Tavis S, Batista LFZ, Mendez J, Sale JE, Vindigni A
Mol Cell 2020 Feb 6;77(3):461-474e9

2019

Defining and Modulating ‘BRCAness’
Byrum AK, Vindigni A, Mosammaparast N
Trends Cell Biol 2019 Sep;29(9):740-751

XLF and H2AX Function in Series to Promote Replication Fork Stability
Chen BR, Quinet A, Byrum AK, Jackson J, Berti M, Thangavel S, Bredemeyer AL, Hindi I, Mosammaparast N, Tyler JK, Vindigni A, Sleckman BP
J Cell Biol 2019 Jul 1;218(7):2113-2123

Ca(2+)-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks From Aberrant Resection
Li S, Lavagnino Z, Lemacon D, Kong L, Ustione A, Ng X, Zhang Y, Wang Y, Zheng B, Piwnica-Worms H, Vindigni A, Piston DW, You Z
Mol Cell 2019 Jun 20;74(6):1123-1137e6

Mitotic Regulators TPX2 and Aurora A Protect DNA Forks During Replication Stress by Counteracting 53BP1 Function
Byrum AK, Carvajal-Maldonado D, Mudge MC, Valle-Garcia D, Majid MC, Patel R, Sowa ME, Gygi SP, Harper JW, Shi Y, Vindigni A, Mosammaparast N
J Cell Biol 2019 Feb 4;218(2):422-432

Perturbing Cohesin Dynamics Drives MRE11 Nuclease-Dependent Replication Fork Slowing
Carvajal-Maldonado D, Byrum AK, Jackson J, Wessel S, Lemacon D, Guitton-Sert L, Quinet A, Tirman S, Graziano S, Masson JY, Cortez D, Gonzalo S, Mosammaparast N, Vindigni A
Nucleic Acids Res 2019 Feb 20;47(3):1294-1310

2018

Superfast DNA Replication Causes Damage in Cancer Cells
Quinet A, Vindigni A
Nature 2018 Jul;559(7713):186-187

A Cell-Intrinsic Interferon-Like Response Links Replication Stress to Cellular Aging Caused by Progerin
Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S
Cell Rep 2018 Feb 20;22(8):2006-2015

2017

Replication Fork Reversal: Players and Guardians
Quinet A, Lemacon D, Vindigni A
Mol Cell 2017 Dec 7;68(5):830-833

Nucleases Acting at Stalled Forks: How to Reboot the Replication Program With a Few Shortcuts
Pasero P, Vindigni A
Annu Rev Genet 2017 Nov 27;51:477-499

Break-Induced Replication Promotes Formation of Lethal Joint Molecules Dissolved by Srs2
Elango R, Sheng Z, Jackson J, DeCata J, Ibrahim Y, Pham NT, Liang DH, Sakofsky CJ, Vindigni A, Lobachev KS, Ira G, Malkova A
Nat Commun 2017 Nov 27;8(1):1790

A Ubiquitin-Dependent Signalling Axis Specific for ALKBH-Mediated DNA Dealkylation Repair
Brickner JR, Soll JM, Lombardi PM, Vagbo CB, Mudge MC, Oyeniran C, Rabe R, Jackson J, Sullender ME, Blazosky E, Byrum AK, Zhao Y, Corbett MA, Gecz J, Field M, Vindigni A, Slupphaug G, Wolberger C, Mosammaparast N
Nature 2017 Nov 16;551(7680):389-393

DNA Fiber Analysis: Mind the Gap!
Quinet A, Carvajal-Maldonado D, Lemacon D, Vindigni A
Methods Enzymol 2017;591:55-82

MRE11 and EXO1 Nucleases Degrade Reversed Forks and Elicit MUS81-Dependent Fork Rescue in BRCA2-Deficient Cells
Lemacon D, Jackson J, Quinet A, Brickner JR, Li S, Yazinski S, You Z, Ira G, Zou L, Mosammaparast N, Vindigni A
Nat Commun 2017 Oct 16;8(1):860

Human Ribonuclease H1 Resolves R-Loops and Thereby Enables Progression of the DNA Replication Fork
Parajuli S, Teasley DC, Murali B, Jackson J, Vindigni A, Stewart SA
J Biol Chem 2017 Sep 15;292(37):15216-15224

Special Issue: “At the Intersection of DNA Replication and Genome Maintenance: From Mechanisms to Therapy”
Vindigni A
Biophys Chem 2017 Jun;225:1-2

Combining Electron Microscopy With Single Molecule DNA Fiber Approaches to Study DNA Replication Dynamics
Vindigni A, Lopes M
Biophys Chem 2017 Jun;225:3-9

2016

The Architectural Chromatin Factor High Mobility Group A1 Enhances DNA Ligase IV Activity Influencing DNA Repair
Pellarin I, Arnoldo L, Costantini S, Pegoraro S, Ros G, Penzo C, Triolo G, Demarchi F, Sgarra R, Vindigni A, Manfioletti G
PLoS One 2016 Oct 10;11(10):e0164258

​Topoisomerase IIbeta Mediates the Resistance of Glioblastoma Stem Cells to Replication Stress-Inducing Drugs
Kenig S, Faoro V, Bourkoula E, Podergajs N, Ius T, Vindigni M, Skrap M, Lah T, Cesselli D, Storici P, Vindigni A
Cancer Cell Int 2016 Jul 26;16:58

​Kinase-Dead ATM Protein Is Highly Oncogenic and Can Be Preferentially Targeted by Topo-Isomerase I Inhibitors
Yamamoto K, Wang J, Sprinzen L, Xu J, Haddock CJ, Li C, Lee BJ, Loredan DG, Jiang W, Vindigni A, Wang D, Rabadan R, Zha S
Elife 2016 Jun 15;5

Replication Stress: Getting Back on Track
Berti M, Vindigni A
Nat Struct Mol Biol 2016 Feb;23(2):103-9

Structural and Biochemical Characterization of an RNA/DNA Binding Motif in the N-Terminal Domain of RecQ4 Helicases
Marino F, Mojumdar A, Zucchelli C, Bhardwaj A, Buratti E, Vindigni A, Musco G, Onesti S
Sci Rep 2016 Feb 18;6:21501