Role of Residue Y99 in Tissue Plasminogen Activator
Vindigni A, Winfield M, Ayala YM, Di Cera E
Protein Sci 2000 Mar;9(3):619-22
Incorporation of Noncoded Amino Acids Into the N-Terminal Domain 1-47 of Hirudin Yields a Highly Potent and Selective Thrombin Inhibitor
De Filippis V, Russo I, Vindigni A, Di Cera E, Salmaso S, Fontana A
Protein Sci 1999 Oct;8(10):2213-7
Energetic Dissection of Specificity in Serine Proteases
Vindigni A
Comb Chem High Throughput Screen 1999 Jun;2(3):139-53
Synthesis and Characterization of More Potent Analogues of Hirudin Fragment 1-47 Containing Non-Natural Amino Acids
De Filippis V, Quarzago D, Vindigni A, Di Cera E, Fontana A
Biochemistry 1998 Sep 29;37(39):13507-15
Role of P225 and the C136-C201 Disulfide Bond in Tissue Plasminogen Activator
Vindigni A, Di Cera E
Protein Sci 1998 Aug;7(8):1728-37
Site-Specific Dissection of Substrate Recognition by Thrombin
Vindigni A, Dang QD, Di Cera E
Nat Biotechnol 1997 Sep;15(9):891-5
Prevention of Vascular and Neural Dysfunction in Diabetic Rats by C-Peptide
Ido Y, Vindigni A, Chang K, Stramm L, Chance R, Heath WF, DiMarchi RD, Di Cera E, Williamson JR
Science 1997 Jul 25;277(5325):563-6
Energetics of Thrombin-Thrombomodulin Interaction
Vindigni A, White CE, Komives EA, Di Cera E
Biochemistry 1997 Jun 3;36(22):6674-81
Energetic Dissection of Specificity in Serine Proteases
Di Cera E, Vindigni A, Banerjee D
In: Thermodymamics and Structure Based Drug Design (Ladbury J, Connelly PR, eds), Landes Co., London, UK, 1997
Thrombin as an Allosteric Enzyme: A Route to Novel Anticoagulants
Di Cera E, Dang QD, Guinto ER, Vindigni A, Nayal M, Ayala YM, Farazi TA, Krem MM, Wallace TM,
BioIt 1996;4:10-13
Release of Fibrinopeptides by the Slow and Fast Forms of Thrombin
Vindigni A, Di Cera E
Biochemistry 1996 Apr 9;35(14):4417-26
The Core Domain of Hirudin From the Leech Hirudinaria Manillensis. Chemical Modification of a Tryptophan-Containing Synthetic Peptide Analog
De Antoni F, De Filippis V, Altichieri L, Vindigni A, Polverino de Laureto P, Fontana A
Adv Exp Med Biol 1996;398:627-33
Linkage at Steady State: Allosteric Transitions of Thrombin
Di Cera E, Dang QD, Ayala Y, Vindigni A
Methods Enzymol 1995;259:127-44
Identification of Residues Linked to the Slow–>Fast Transition of Thrombin
Guinto ER, Vindigni A, Ayala YM, Dang QD, Di Cera E
Proc Natl Acad Sci U S A 1995 Nov 21;92(24):11185-9
Thermodynamic Investigation of Hirudin Binding to the Slow and Fast Forms of Thrombin: Evidence for Folding Transitions in the Inhibitor and Protease Coupled to Binding
Ayala YM, Vindigni A, Nayal M, Spolar RS, Record MT Jr, Di Cera E
J Mol Biol 1995 Nov 10;253(5):787-98
The Na+ Binding Site of Thrombin
Di Cera E, Guinto ER, Vindigni A, Dang QD, Ayala YM, Wuyi M, Tulinsky A
J Biol Chem 1995 Sep 22;270(38):22089-92
Core Domain of Hirudin From the Leech Hirudinaria Manillensis: Chemical Synthesis, Purification, and Characterization of a Trp3 Analog of Fragment 1-47
De Filippis V, Vindigni A, Altichieri L, Fontana A
Biochemistry 1995 Jul 25;34(29):9552-64
An Allosteric Switch Controls the Procoagulant and Anticoagulant Activities of Thrombin
Dang OD, Vindigni A, Di Cera E
Proc Natl Acad Sci U S A 1995 Jun 20;92(13):5977-81
Probing the Structure of Hirudin From Hirudinaria Manillensis by Limited Proteolysis. Isolation, Characterization and Thrombin-Inhibitory Properties of N-Terminal Fragments
Vindigni A, De Filippis V, Zanotti G, Visco C, Orsini G, Fontana A
Eur J Biochem 1994 Dec 1;226(2):323-33