We focus on DNA replication and repair, and the roles of these pathways on cancer initiation, progression and response to chemotherapy and immunotherapy.
We use a unique combination of biochemical, cellular, and electron microscopy approaches to study perturbations of replication fork dynamics at single-molecule resolution. Combining these technologies, we identified new pathways by which replication responds to DNA damaging chemotherapeutics and provided insights on how to target these pathways to increase chemotherapeutic sensitivity.
We are part of the newly established Siteman Center for Genome Integrity that fosters interactions between clinical and basic science investigators interested in genome integrity and DNA repair.